Friday, 15 February 2013

How does exercise affect the brain?


One of the most interesting things about neuroscience is that your brain isn’t restricted to a certain about of neurons. A neuron is a cell that is part of the body’s nervous system, which transmits and receives electrical and chemical signals. It has the ability to send information over a long distance due to its electrochemical aspect. It has a structure of three main parts: soma, axon and dendrites. The soma is the body of the cell, it contains the nucleus that holds the majority of RNA, also in the cell there are ribosomes and endoplasmic reticulum. The function of the axon is to transmit information to other muscles, organs and cells through electrical impulses. Some types of neuron have no Axon so they emit the signals from their dendrites. However the main role of the dendrite is to process the electrochemical signal received from other neural cells, this would explain why sensory neurons have dendrites on both end of the cell.

Our brains are made of around 100 billion neural cells, produced during pre-natal development. However our brain can create new ones during neurogenesis in the hippocampus and sub ventricular zone.  During this process neural stem cells are capable to differentiate into brain neurons via external stimulus. Once these cells have become specialised the brain is replenished with unspecialised cells, giving them the opportunity to differentiate in to new neurons providing no limit of the brain’s capacity.

Research has shown for exercise to cause neurogenesis, due to the production of BDNF (Brain-Derived-Neurotrophic Factor) proteins. When you exercise it is believed BDNF is released due to the stress factor, in order to protect current neurons as well a promote the production of new ones. The other purpose of BDNF production is to promote the ability of connection between two neurons to change in strength in response to stimuli, this is known as Synaptic plasticity. BDNF is secreted due to the influx in calcium (which is due to the rise in stress levels) because it causes transcription on nerve cells within the hippocampus and the transcription causes the secretion of BDNF. MK McGovern on his article about the effect of exercise on the brain he also describes BDNF as ‘reparative’, during exercise the axons are regenerated by injured neurons by ‘neutrophin-signalling mechanism’

The hippocampus has an important job in consolidating long and short-term memory as well as spatial navigation. It is believed that the hippocampus provides declarative memory, which is long-term memory using knowledge and facts. So therefore with an increase in neurons in the hippocampus, more electrical signals can be passed around, so you’re better at memorising things. For things to be remembered, there has to be certain strength between the neurons, if two neurons receive an electrical signal then they will communicate better in the future, this is known as long-term potentiation.  

To conclude, exercise does have an effect on the brain due to the production of new nerve cells during neurogenesis which happens in the response to stress.



References

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